CBD and Interactions between medicine

Another frequently asked question is: can CBD-containing products be used at the same time as synthetic classical medicine? We will try to shed some light on this.

Drug interactions are very common, especially in the elderly, who are treating pain, diabetes and high cholesterol. The geriatric population (people over 60) is also the fastest-growing group of medical cannabis users. It is therefore important to emphasize that cannabinoids can interact with conventional medicines, both to potentiate and to prevent negative interactions while taking advantage of situations where Cannabis and drugs act synergistically.

Interactions with medicines can be both helpful and dangerous. For example, opiate-boosting medicines may increase the analgesic effect, but may also increase the likelihood of overdose. Or the second thing is that CBD as an analgesic could reduce the dose of the opiate, which would slow down tolerance and reduce other side effects.

But it is relatively difficult to know the converging biological pathways of any two medicines. Examination of medicines metabolism interactions is one way to predict drug interactions in general: since more than half of all medicines are metabolized by a group of enzymes called cytochrome P450 (CYP), knowing how cannabinoids affect CYP provides a good first approximation. Phytocannabinoid and medicines interactions. In general, inhibition of CYP, which metabolizes the drug, will increase its blood levels, leading to an increase in both exposure and toxicity. But for pre-existing medicines that are metabolized to the active compound, inhibition of metabolism will reduce both the desired and adverse effects. And interactions can vary from delayed to activated with different drugs. Due to complications such as these, it is much easier to predict whether drug interactions are possible than to predict their exact effects.

CBD can change the way your body handles certain medications.
Cannabidiol (CBD) has received widespread attention for its potential to reduce the symptoms of insomniaanxietychronic pain, and many other health conditions.

And while research into the effectiveness of CBD continues, many people try it and incorporate it into their daily routine.

Studies to date have shown that CBD is generally safe and has few, if any, minor side effects. However, there is one important caveat: CBD has the potential to interact with certain medications. Concerns relate to how the body metabolizes certain substances.

Before trying CBD, it is very important to talk to your doctor about all the vitamins, supplements, and prescription and over-the-counter medications you are taking. Let’s take a closer look at why conversation is important.

The metabolism of medicines and CYP450 enzymes.
When taking medicines or other substances, your body needs to metabolize or break them down. The metabolism of medicines occurs throughout the body, such as in the gut, but the liver also does a large part of the work.

The enzyme family, called the reliable source of cytochrome P450 (CYP450), plays an important role in transforming foreign substances so that they can be easily removed from the body.

Cytochrome P450 is a group of liver enzymes that are responsible for breaking down drugs and toxins that enter the body. By inhibiting the activity of this enzyme, CBD may temporarily deactivate its activity, which may alter the metabolism of other compounds.

However, some drugs or substances affect CYP450 by slowing or accelerating drug metabolism. These changes in metabolic rate can change the way your body handles the medicines or supplements you take – and therefore the drug interactions.

CBD can reduce or potentiate the effects of certain prescribed drugs by interacting with receptors throughout the body’s endocannabinoid system (ECS) and inhibiting cytochrome P450 activity.

Why is CYP450 important when it comes to CBD and medicines?
The CYP450 family of enzymes is responsible for the metabolism of several cannabinoids, including CBD, studies suggest. In particular, this function is performed by CYP3A4, an important enzyme in the CYP450 family. But during this process, CBD also interferes with CYP3A4.

The CYP3A4 enzyme is responsible for the metabolism of approximately 60% of metabolites. But if CBD inhibits CYP3A4, it may not work as effectively to break down the medicines in your system.

The opposite can also happen. Many medicines inhibit CYP3A4. If you then take CBD while taking these medicines at the same time, your body may not be able to treat CBD as effectively.

If your body metabolizes medicines too slowly, you may have more medicines in your system at once than you should, even if you have followed the usual dose.

Elevated levels of the medicines in your system can exaggerate its effects, including unwanted or harmful side effects.

Try CBD safely while taking medication.
If you want to try CBD as adjunctive therapy to relieve the symptoms of a certain condition, talk to your doctor first, as long as he or she has information about the use of Cannabis in therapy and in the improvement of various health conditions.

They can help determine a CBD product, dosage, and schedule that is safe with your medication. In some situations, your doctor may want to monitor the plasma levels of certain medicines.

Do not stop taking the medicines to try CBD unless your doctor is sure it is safe to do so.

Note that topical CBDs, such as lotions, creams and ointments, may also be an option. Unlike oils, foods, and solutions, topical medications usually do not enter the bloodstream unless they are the transdermal solutions for which they are intended.

Possible interactions.

  • Interactions between CBD and medications that increase the risk of bleeding.

Studies have shown that CBD and other herbal cannabinoids may potentiate the effects of medicines used to thin the blood or medicines that risk blood thinning.

By slowing down the way the medicine is metabolized by the body, CBD maintains the strength of the medicine and prolongs its presence in the body. CBD can be effective in increasing and prolonging the effects of medicines that increase the risk of bleeding, and the concomitant use of both medicines should be closely monitored by a medical professional.

  • Interaction between CBD and sedatives.

By interacting with neurotransmitter receptors in the central nervous system, cannabinoids such as CBD and THC may cause sedative effects on the user. While the sedative effects of THC are associated with somnolence and lethargy, CBD has a sedative effect.

When combined with sedatives, cannabinoids have an additive effect, which means that they may increase the effects of the medicine. Although the interaction between CBD and sedatives does not appear to have a direct negative impact on the user, the potential effects of CBD on sedatives are not fully understood.
To be safe, users should avoid combining CBD with strong sedatives.

  • CBD interactions with anticonvulsants.

Although CBD is widely known to be effective in treating epileptic seizures, CBD can cause anticonvulsant problems under certain conditions without medical supervision.

A 1992 study by Lester Bornheim found that a low dose of CBD would not provide significant antiepileptic benefits; however, it will still inhibit the activity of cytochrome p450 enzymes and lead to prolonged clobazam concentrations, which may in fact lead to more aggressive seizures.

With this in mind, it is very important to consult a medical professional to determine the correct dose of CBD to effectively reduce epileptic seizures.

  • Interaction between CBD and chemotherapy drugs.

The interaction between CBD and a course of chemotherapy creates a similar situation.

Accurate dosing of chemotherapy is extremely important in the treatment of tumors.
Insufficient amounts can lead to inefficiencies and excessive amounts can lead to excessive toxicity.

Many chemotherapy drugs are formulated so that the drug will be metabolized at a certain rate before it enters the body. Adding CBD therapy may delay the metabolic process, which may result in higher than expected blood levels of the drug.

Although CBD has shown to reduce oncology-related pain and slow the growth of cancer cells when combined with chemotherapy, the amount and type of anticancer drugs administered should take into account the presence of CBD.

Look for a warning about grapefruit !!!
Although research is still underway to determine the possible interaction between CBD and certain medications, there is still one ”cheat sheet” that can help consumers: be careful with CBD if your medication has a grapefruit warning on the label.

This warning indicates that people taking medicine should avoid grapefruit or grapefruit juice.

According to the Food and Drug Administration, taking grapefruit with one of these drugs can lead to higher blood levels of the drug and side effects or even overdose.

More than 85 medicines interact with grapefruit and some closely related citrus juices, such as Seville oranges, pomelo and tangelos. This is because chemicals in grapefruit known as furanocoumarins or furocoumarins inhibit CYP3A4, similar to CBD. The result is a slowed drug metabolism.

Warnings about grapefruit are common in several types of medicines, but not all medicines in the same category should avoid “grapefruit”.

Check the information that came with the medicine or ask your doctor.

Types of medicines that are usually warned about interactions with grapefruit:
⦁ antibiotics and antibacterial agents
⦁ anticancer medicines
⦁ Antihistamines
⦁ antiepileptic drugs (AEDs)
⦁ medicines for high blood pressure
⦁ blood thinners
⦁ Cholesterol drugs
⦁ corticosteroids
⦁ medicines for erectile dysfunction
⦁ GI medicines such as GERD or nausea
⦁ heart rhythm medicine
⦁ immunosuppressants
⦁ medicines used to treat mood disorders such as anxiety, depression or mood disorders
⦁ painkillers
⦁ prostate medicine.

For more information, see a list of some medications that can interact with grapefruit juice that are listed on Drugs.com

Current research on CBD and drug interactions.
Researchers continue to study and work to determine the specific interactions between CBD and various drugs. Studies have been done about animals on certain drugs, but in many cases, scientists are still studying how these results work for humans.

Some small clinical trials have been performed. For example, in one study of 25 children with hard-to-treat epilepsy, 13 children received both clobazam and CBD. The researchers found elevated levels of clobazam in these children. They report that CBD and clobazam are safe to use together, but recommend that medication levels be monitored during treatment.

In another study, Epidiolex with CBD was also given to 39 adults and 42 children taking anti-epileptic medicines. CBD doses were increased every 2 weeks.
The researchers observed antiepileptic drug levels in the subjects over time. While the serum levels remained within the accepted therapeutic range for most of them, two drugs, clobazam and desmethylclobazam, had serum levels outside the therapeutic range.

Preliminary studies show that CBD can definitely interfere with the level of medication in your body, even if you take the prescribed dose. But more research is needed to determine the extent of CBD interactions between different drugs and to develop recommendations for their use with CBD.

Safety and side effects.
Under close medical supervision, you may still be able to safely take CBD with medication, even those who are warned about grapefruit.

If necessary, your doctor may monitor the plasma levels of your medicines. They may also choose to monitor your liver function.

If you are taking CBD with medication, it is important to keep track of any changes in how the medication or CBD affects you.

Possible side effects to look out for.

exacerbated or new adverse drug reactions, such as:

  • drowsiness;
  • sedation;
  • nausea.

reduction in the effectiveness of medicines, for example:

  • seizures.

common side effects or changes in CBD, such as:

  • fatigue;
  • diarrhea;
  • changes in appetite;
  • weight changes.

Talk to your doctor.
The key is to always consult a doctor if you want to try CBD, especially if you have a medical condition and you are taking serious medications. It is important to note that consultation will only be valuable with a medical professional who specializes in the use of CBD as adjunctive therapy. Do not stop taking prescription medications to try CBD unless you have consulted a doctor. You can try several admission methods until you find the best one that best suits your needs.

Medicines that come with a warning about grapefruit are likely to interact with CBD. However, even if you are taking any of these medicines, your doctor may be able to formulate a plan that works for you by closely monitoring the level of the medicine in your body. This way you can use both medication and CBD as therapy.

Your doctor or pharmacist may also recommend a quality CBD product that meets your needs. When researching CBD labels, you can also find reputable products with a little research at the bottom.


⦁ Alsherbiny MA, et al. (2018). Medicinal cannabis — potential drug interactions.
⦁ Bailey DG, et al. (2013). Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?:
⦁ Grapefruit juice and some drugs don’t mix: Grapefruit juice can affect how well some medicines work, and it may cause dangerous side effects. (2017).

In conclusion.
Note that the possible interactions between CBD and medication discussed here are mentioned only because this is also the case and you need to be careful with yourself or your relatives while taking CBD and medication at the same time.

Interactions with medications can be both helpful and dangerous.

  • THC and CBD interact with many common medicines. Cannabinoids may inhibit or potentiate the effects of various drugs.
  • More than half of all drugs – including THC and CBD – are metabolized by a group of enzymes called cytochrome P450.
  • Interactions between cannabinoids and other drugs can be used to reduce side effects while synergistically improving the patient’s quality of life.
  • The interaction between cannabinoids and opioids shows great therapeutic potential. THC significantly enhances the analgesic effect of opiates, while CBD is the most promising for reducing addiction and dependence.

The information on the Internet about CBD products and their use will be ambiguous, so we always recommend reading safe and reliable sources. We also use websites related to the Cannabis industry, research and education to prepare information.

The information on the internet about CBD products and their use will be ambiguous, so we always recommend reading safe and reliable sources. We also use websites related to the Cannabis industry, research and education to prepare information.

The content of this site is for informational purposes only. We are not medical experts and this should not be interpreted as medical advice. Be sure to consult your doctor before undergoing CBD or other treatment.

The chemistry of every human body and brain is unique, so the use of CBD to improve mental as well as physical health does not guarantee results. However, many GWEEPRODUCTS CBD oil users have included it into their daily routine as one of the therapies for improving mental, physical health and quality of life.

References: projectcbd.org; cbdorign.com; healthline.com; drugs.com; ncbi.nlm.nih.gov

Photo from Unsplash.

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